Alpha-GPC

Also known as alpha gpc, choline alfoscerate, l-alpha glycerylphosphorylcholine.

Last reviewed October 9, 2026 · Jump to references

What is Alpha-GPC?

In plain words

Alpha-GPC is a choline-containing substance related to the fats that make up cell membranes. The body uses its choline to make acetylcholine, a chemical that helps nerve cells communicate, and to build cell membranes. Researchers study it for memory, thinking skills, and physical performance. Evidence for benefits in healthy adults is limited, and long-term safety remains uncertain.

Technical definition

Alpha-GPC (choline alfoscerate; L-alpha-glycerylphosphorylcholine) is a choline-containing metabolite of phosphatidylcholine, with choline linked through phosphate to a glycerol backbone. It supplies choline for acetylcholine synthesis and membrane phospholipid metabolism, acting as a metabolic precursor rather than a direct acetylcholine-receptor agonist. It is marketed as a dietary supplement in the United States, where it is not an FDA-approved drug, and as a medicine in some other countries.

Educational information only. This page does not provide medical advice or determine whether a supplement is appropriate for you. Review supplements with a qualified healthcare professional, especially if you take medication, are pregnant, have surgery scheduled, or have a chronic medical condition.

Evidence by use

Each use is rated on its own. There is no single overall effectiveness score.