Chloride

Also known as electrolyte, electrolytes, sodium chloride.

Last reviewed October 9, 2026 · Jump to references

What is Chloride?

In plain words

Chloride is a mineral that carries an electrical charge and is one part of table salt. The body uses it to balance fluids, help nerves work, and make stomach acid, while the kidneys control how much stays in the blood. Researchers study its role in hydration, kidney function, and blood acidity. Too much or too little chloride in the blood can signal a health problem.

Technical definition

Chloride (Cl−) is the negatively charged ion of chlorine and the principal extracellular anion, commonly obtained from dietary salts such as sodium chloride. Rather than acting at a single receptor, it moves through chloride channels and membrane transporters to support fluid balance, acid–base regulation, electrical signaling, and gastric hydrochloric acid production. Chloride salts are regulated according to their formulation and intended use, including as food ingredients, dietary supplements, and medicines.

Educational information only. This page does not provide medical advice or determine whether a supplement is appropriate for you. Review supplements with a qualified healthcare professional, especially if you take medication, are pregnant, have surgery scheduled, or have a chronic medical condition.

Evidence by use

Each use is rated on its own. There is no single overall effectiveness score.