Conjugated linoleic acid / CLA

Also known as CLA, conjugated linolenic acid.

Last reviewed October 9, 2026 · Jump to references

What is Conjugated linoleic acid / CLA?

In plain words

CLA is a group of fats found naturally in beef, lamb, and dairy foods, and also sold in supplements. The body can burn it for energy or build it into cells and stored fat. Researchers study whether it changes body fat, muscle mass, and blood sugar control. Human studies show small or inconsistent body-fat benefits, and some forms may make it harder for the body to control blood sugar.

Technical definition

Conjugated linoleic acid (CLA) is a family of 18-carbon polyunsaturated fatty-acid isomers with two conjugated double bonds, found naturally in ruminant meat and dairy fat. CLA isomers can modulate peroxisome proliferator-activated receptor (PPAR) signaling and lipid metabolism, with biological effects differing by isomer. CLA is marketed in the United States as a dietary supplement, not an FDA-approved drug.

Educational information only. This page does not provide medical advice or determine whether a supplement is appropriate for you. Review supplements with a qualified healthcare professional, especially if you take medication, are pregnant, have surgery scheduled, or have a chronic medical condition.

Evidence by use

Each use is rated on its own. There is no single overall effectiveness score.