DIM

Also known as diindolylmethane, 3,3-diindolylmethane.

Last reviewed October 9, 2026 · Jump to references

What is DIM?

In plain words

DIM is a compound formed during digestion from substances in vegetables such as broccoli and cabbage. The body breaks it down for removal, and it can change how estrogen is processed. Researchers study its effects on hormone activity and cancer-related processes. Human evidence is limited, and DIM supplements have not been proven to prevent or treat cancer.

Technical definition

3,3′-Diindolylmethane (DIM) is an indole-derived compound containing two indole rings linked by a methylene group, formed through acid-mediated conversion of indole-3-carbinol from cruciferous vegetables. It modulates aryl hydrocarbon receptor (AhR) signaling and enzymes involved in estrogen metabolism, with effects that depend on biological context. DIM is marketed in the United States as a dietary supplement and is not an FDA-approved drug.

Educational information only. This page does not provide medical advice or determine whether a supplement is appropriate for you. Review supplements with a qualified healthcare professional, especially if you take medication, are pregnant, have surgery scheduled, or have a chronic medical condition.

Evidence by use

Each use is rated on its own. There is no single overall effectiveness score.