Lion’s mane

Also known as hericium erinaceus, lions mane, lion's mane mushroom.

Last reviewed October 9, 2026 · Jump to references

What is Lion’s mane?

In plain words

Lion’s mane is an edible mushroom also sold as a supplement. The body breaks down some of its ingredients, while some mushroom fibers reach the gut and interact with gut bacteria. Researchers study it for possible effects on memory, mood, and nerve health. Human studies are small and limited, and allergic reactions or stomach upset can occur.

Technical definition

Lion’s mane (Hericium erinaceus) is an edible fungus used in dietary supplements; its constituents include polysaccharides, hericenones associated with the fruiting body, and erinacines associated with the mycelium. It has no established single molecular target in humans, although preclinical studies suggest that certain constituents influence nerve growth factor signaling and inflammatory pathways. In the United States, lion’s mane supplements are not FDA-approved treatments for disease.

Educational information only. This page does not provide medical advice or determine whether a supplement is appropriate for you. Review supplements with a qualified healthcare professional, especially if you take medication, are pregnant, have surgery scheduled, or have a chronic medical condition.

Evidence by use

Each use is rated on its own. There is no single overall effectiveness score.