Papain

Also known as papaya enzyme.

Last reviewed October 9, 2026 · Jump to references

What is Papain?

In plain words

Papain is a protein-cutting enzyme from papaya. It breaks proteins into smaller pieces and, like other proteins, can itself be broken down during digestion. Researchers study it for digestive support and for removing damaged tissue from wounds. Evidence for benefits from oral supplements is limited, and papain can cause allergic reactions.

Technical definition

Papain is a plant-derived cysteine protease obtained from the latex of papaya (Carica papaya), with a mature structure consisting of a single 212-amino-acid chain. Rather than acting through a receptor, it uses an active-site cysteine–histidine pair to hydrolyze peptide bonds in proteins. Papain is used in food processing and marketed in dietary supplements; supplement status does not constitute approval as a medicine.

Educational information only. This page does not provide medical advice or determine whether a supplement is appropriate for you. Review supplements with a qualified healthcare professional, especially if you take medication, are pregnant, have surgery scheduled, or have a chronic medical condition.

Evidence by use

Each use is rated on its own. There is no single overall effectiveness score.