Phosphatidylserine

Also known as PS, phosphatidyl serine.

Last reviewed October 9, 2026 · Jump to references

What is Phosphatidylserine?

In plain words

Phosphatidylserine is a fatty substance found in cell membranes, including those of brain cells. The body breaks down dietary PS and uses its parts to build and renew membrane fats. Researchers study it for memory, thinking skills, and stress responses. Evidence for meaningful benefits remains limited, and it has not been proven to prevent or treat dementia.

Technical definition

Phosphatidylserine (PS) is a glycerophospholipid composed of a glycerol backbone, two fatty-acid chains, and a phosphate-linked serine head group; it is concentrated in the inner leaflet of cell membranes. Rather than acting through one specific receptor, it supports membrane organization and regulates membrane-associated signaling proteins; its exposure on the cell surface also helps signal clearance of dying cells. In the United States, PS is marketed as a dietary supplement, not an FDA-approved treatment for cognitive decline.

Educational information only. This page does not provide medical advice or determine whether a supplement is appropriate for you. Review supplements with a qualified healthcare professional, especially if you take medication, are pregnant, have surgery scheduled, or have a chronic medical condition.

Evidence by use

Each use is rated on its own. There is no single overall effectiveness score.