Protease

Also known as proteolytic enzymes.

Last reviewed October 9, 2026 · Jump to references

What is Protease?

In plain words

Proteases are enzymes that break proteins into smaller pieces. The body makes its own proteases to digest food and break down or recycle proteins in tissues. Researchers study specific proteases for digestion, wound care, and inflammation. Evidence and safety differ by enzyme and purpose; benefits found for one do not necessarily apply to others.

Technical definition

Proteases, also called proteolytic enzymes, are a diverse class of protein enzymes produced by animals, plants, and microorganisms that catalyze the hydrolysis of peptide bonds in proteins. Their targets are protein or peptide substrates rather than a single receptor, and their mechanisms vary by enzyme family. Regulatory status depends on the specific enzyme and product: some are components of approved medicines, while others are sold as dietary supplements without approval as disease treatments.

Educational information only. This page does not provide medical advice or determine whether a supplement is appropriate for you. Review supplements with a qualified healthcare professional, especially if you take medication, are pregnant, have surgery scheduled, or have a chronic medical condition.

Evidence by use

Each use is rated on its own. There is no single overall effectiveness score.