SAM-e

Also known as s-adenosylmethionine, same, sam e.

Last reviewed October 9, 2026 · Jump to references

What is SAM-e?

In plain words

SAM-e is a substance the body makes naturally from methionine, a building block of protein. The body uses it to transfer small chemical groups that help make and modify other molecules. Researchers study it for depression, joint pain from arthritis, and some liver conditions, but evidence of benefit is mixed. It can interact with antidepressants and may trigger mania in people with bipolar disorder.

Technical definition

S-adenosylmethionine (SAM-e) is an endogenous sulfonium metabolite synthesized from methionine and ATP by methionine adenosyltransferase. Rather than acting through a single receptor, it serves as a methyl-group donor for methyltransferases and participates in pathways involved in polyamine synthesis and sulfur-containing metabolite production. SAM-e is marketed as a dietary supplement in the United States, where it is not FDA-approved to treat disease; regulatory status differs internationally.

Educational information only. This page does not provide medical advice or determine whether a supplement is appropriate for you. Review supplements with a qualified healthcare professional, especially if you take medication, are pregnant, have surgery scheduled, or have a chronic medical condition.

Evidence by use

Each use is rated on its own. There is no single overall effectiveness score.