Sulforaphane

Also known as sulphoraphane, glucoraphanin.

Last reviewed October 9, 2026 · Jump to references

What is Sulforaphane?

In plain words

Sulforaphane is a substance made from a compound in broccoli and related vegetables when they are chopped or chewed. After absorption, it activates some of the body's cell-protection systems and is then broken down and removed mainly in urine. Researchers study its effects on inflammation, blood sugar control, and processes linked to cancer. Human studies are still limited and do not establish it as a disease treatment.

Technical definition

Sulforaphane is a naturally occurring isothiocyanate formed when the enzyme myrosinase hydrolyzes glucoraphanin, a distinct precursor compound found in cruciferous vegetables such as broccoli. It modifies cysteine residues on KEAP1, stabilizing the transcription factor NRF2 and promoting expression of antioxidant and cellular defense genes. It is sold in dietary supplements but is not FDA-approved as a treatment for disease.

Educational information only. This page does not provide medical advice or determine whether a supplement is appropriate for you. Review supplements with a qualified healthcare professional, especially if you take medication, are pregnant, have surgery scheduled, or have a chronic medical condition.

Evidence by use

Each use is rated on its own. There is no single overall effectiveness score.