5-Amino-1MQ

Research Use

Also known as 5A1MQ, NNMT inhibitor

Function

Primary

Fat loss · Muscle preservation (research)

Mechanism

Small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — restores cellular NAD+/SAM balance, enhances adipocyte lipolysis and myocyte regeneration.

Evidence

Pre-clinical / Observational

Research

Pre-clinical (rodent models of obesity & sarcopenia)

Dosing

Range

50–150 mg/day (anecdotal human use)

Frequency

Daily

Route

Oral

Cycling

Reported 8–12 week cycles in user protocols; not validated.

Benefits

·Reduces adiposity in rodents
·Improves muscle stem-cell function
·May support metabolic flexibility

Risks

·Unknown human safety
·Potential off-target methylation effects
·No long-term data

Contraindications

·Pregnancy / lactation
·Hepatic impairment (caution)

Regulatory

Research chemical — not approved for human use

Functional Groups

Weight Loss Longevity

Cited Works

Neelakantan H et al. Selective NNMT inhibitor (5-Amino-1MQ) reverses diet-induced obesity. Biochem Pharmacol. 2018;147:141.source

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