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ACE-031
Research Use
Also known as ACVR2B-Fc, Soluble activin receptor
Function
Primary
Muscle mass increase (investigational)
Mechanism
Soluble activin receptor type IIB fusion protein that sequesters myostatin and related ligands, removing the brake on muscle growth.
Evidence
Clinical RCT (Limited)
Research
Phase II in Duchenne muscular dystrophy halted (2013)
Dosing
Range
1–3 mg/kg (trial dosing)
Frequency
Every 2–4 weeks
Route
Subcutaneous
Administration & Technique
Subcutaneous (SubQ)
Default route for most research and therapeutic peptides — best absorption for reconstituted powder.
Device31G × 5/16" insulin syringe (U-100). 100 units = 1 mL.
TechniquePinch skin at abdomen (2" from navel), outer thigh, or love handle. Insert at 45–90°. Rotate sites daily to prevent lipohypertrophy. Alcohol-swab site, air-dry, inject slow, hold 5 sec.
Injection & Application Sites
Front
Back
Subcutaneous (SubQ)
- Abdomen — 2 in (5 cm) away from the navel, either side. Fastest, most consistent SubQ absorption.
- Flank / love handle — Lateral fat pad above the hip. Good rotation site when the abdomen is tender.
- Outer thigh — Upper outer quadrant, a hand-width below the hip. SubQ pinch at 45°.
Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.
Cycling
No safe consumer protocol exists; listed for reference only.
Timing & Interactions
When to take
No strict time-of-day requirement. Dose consistently at the same time daily and rotate injection sites. Follow the per-peptide dosing section above.
Do not combine with
- ·Avoid stacking with peptides that share the same receptor or mechanism without clinical guidance.
- ·Avoid combining with alcohol or immunosuppressants unless cleared by a clinician.
Complements
- ·Most peptides pair safely with baseline nutrition, sleep, and resistance training.
Storage & Reconstitution
Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Reconstitution Calculator
Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)
1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.
Your Notes
Your Notes
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Benefits
- ·Marked lean-mass gain in trials
- ·Reduced fat mass
Risks
- ·Nosebleeds and gum bleeding
- ·Telangiectasia
- ·Vascular/hematologic adverse events that ended development
Contraindications
- ·Bleeding disorders
- ·Vascular disease
- ·Pregnancy
- ·Any non-supervised use
Regulatory
Development discontinued after safety signals
Veterinary Use (Pets)
No established veterinary protocol for ACE-031. Consult a licensed veterinarian before considering off-label use in any species.
Full veterinary reference →Functional Groups
Cited Works
- Lee SJ. Quadrupling muscle mass in mice by targeting myostatin & follistatin. PLoS ONE. 2007;2:e789.source