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Argireline
Research Use
Also known as Acetyl Hexapeptide-3, Acetyl Hexapeptide-8
Function
Primary
Expression lines · Forehead/crow's-feet wrinkles
Mechanism
Mimics SNAP-25 N-terminus — competitively inhibits SNARE complex formation, reducing catecholamine release and micro-contractions in mimic muscles.
Evidence
Clinical RCT (Limited)
Research
Cosmetic RCTs vs placebo
Dosing
Range
5–10% in topical formulation
Frequency
1–2× daily
Route
Topical
Cycling
Continuous topical use.
Benefits
- ·Reduces expression-line depth
- ·Non-invasive 'topical botox' alternative
- ·Well tolerated
Risks
- ·Mild irritation
- ·Modest effect vs injectables
Contraindications
- ·Application on broken skin
Regulatory
Cosmetic ingredient (global)
Functional Groups
Cited Works
- Blanes-Mira C et al. A synthetic hexapeptide (Argireline) inhibits neuronal exocytosis. Int J Cosmet Sci. 2002;24:303.source