← Library
Bremelanotide
FDA ApprovedSince 2019
Also known as Vyleesi
Function
Primary
Hypoactive Sexual Desire Disorder (premenopausal women)
Mechanism
MC1R/MC4R agonist — centrally activates melanocortin pathways modulating sexual desire and arousal.
Evidence
Clinical RCT (Phase III)
Research
Phase III RECONNECT trials
Dosing
Range
1.75 mg PRN
Frequency
As needed (max 1×/24h, ≤8/month)
Route
Subcutaneous (autoinjector)
Administration & Technique
Subcutaneous
45 min before anticipated activity. Max 1 dose / 24 h, 8 / month.
DevicePre-filled auto-injector (Vyleesi) — 1.75 mg fixed dose.
TechniqueAbdomen or thigh. One-time single-use device.
Injection & Application Sites
Front
Back
Subcutaneous
- Abdomen — 2 in (5 cm) away from the navel, either side. Fastest, most consistent SubQ absorption.
- Outer thigh — Upper outer quadrant, a hand-width below the hip. SubQ pinch at 45°.
Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.
Cycling
PRN only; max 8 doses/month.
Timing & Interactions
When to take
SubQ 45 min before anticipated sexual activity. Do not exceed 1 dose per 24 hrs or 8 doses per month.
Do not combine with
- ·Uncontrolled hypertension — bremelanotide transiently raises BP
- ·Concurrent Melanotan II — same melanocortin class
- ·Naltrexone (oral) — reduced efficacy
Complements
- ·Kisspeptin-10 (research) for HPG-axis pairing
Storage & Reconstitution
Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Reconstitution Calculator
Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)
1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.
Your Notes
Your Notes
Sign in to save personal notes on Bremelanotide and sync them to Vial Lab.
Benefits
- ·Increases sexual desire scores
- ·On-demand dosing
Risks
- ·Nausea (~40%)
- ·Flushing
- ·Transient BP increase
- ·Hyperpigmentation
Contraindications
- ·Uncontrolled hypertension
- ·Known CV disease
Regulatory
FDA-Approved Rx
Veterinary Use (Pets)
No established veterinary protocol for Bremelanotide. Consult a licensed veterinarian before considering off-label use in any species.
Full veterinary reference →Functional Groups
Cited Works
- Kingsberg SA et al. Bremelanotide for HSDD: Phase 3 RECONNECT Trials. Obstet Gynecol. 2019;134:899.source