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Dihexa
Research Use
Also known as PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
Function
Primary
Cognitive enhancement (research) · Synaptogenesis
Mechanism
Small peptide HGF/c-Met mimetic — promotes formation of new functional synapses; ~7-orders-of-magnitude more potent than BDNF in vitro.
Evidence
Pre-clinical / Observational
Research
Pre-clinical rodent cognition models
Dosing
Range
8–45 mg/day (anecdotal oral/transdermal)
Frequency
Daily
Route
Oral · Transdermal
Cycling
Short cycles reported; no validated protocol.
Benefits
- ·Marked synaptogenesis
- ·Memory enhancement in rodent AD models
- ·Oral bioavailability
Risks
- ·No human safety data
- ·Theoretical mitogenicity via HGF/c-Met
- ·Anxiety / overstimulation reported
Contraindications
- ·Cancer history
- ·Pregnancy
Regulatory
Research chemical — not approved
Functional Groups
Cited Works
- McCoy AT et al. Dihexa, a small molecule HGF mimetic enhances cognition. J Pharmacol Exp Ther. 2013;344:141.source