Epithalon

Research Use

Also known as Epitalon, Epithalamin

Function

Primary

Telomere elongation · Anti-aging

Secondary

Circadian regulation · Oncostatic (research)

Mechanism

Tetrapeptide — activates telomerase enzyme; regulates melatonin secretion via pineal gland; antioxidant; normalizes cortisol/sex hormone decline with aging.

Evidence

Pre-clinical / Observational

Research

Russian animal and limited human observational data (Khavinson)

Dosing

Range

5–10 mg/day (10–20-day cycles)

Frequency

Daily within short cycles

Route

Subcutaneous · Intravenous

Cycling

10–20 days daily, 2–4 cycles per year.

Benefits

·Reported telomerase activation in vitro
·Sleep and circadian improvement
·Anti-aging biomarker support (preliminary)

Risks

·Limited human RCT data
·Long-term safety unproven
·Sourcing concerns

Contraindications

·Active malignancy (theoretical)
·Pregnancy

Regulatory

Not FDA-approved; research use

Functional Groups

Longevity

Cited Works

Khavinson VK et al. Epitalon peptide and telomerase activation. Bull Exp Biol Med. 2003;135:590.source

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