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FOXO4-DRI
Research Use
Also known as FOXO4-D-Retro-Inverso
Function
Primary
Senescent cell clearance (research)
Mechanism
D-retro-inverso peptide disrupts FOXO4–p53 interaction in senescent cells — selectively triggers apoptosis in senescent (not healthy) cells.
Evidence
Pre-clinical / Observational
Research
Pre-clinical (Baar et al. 2017)
Dosing
Range
5 mg/kg in mice; no validated human dose
Frequency
Intermittent in trials
Route
Intravenous · Intraperitoneal (research)
Cycling
Intermittent / pulse dosing in animal models.
Benefits
- ·Selective clearance of senescent cells
- ·Improved fitness, fur density, renal function in aged mice
Risks
- ·No human safety data
- ·Potential off-target apoptosis
- ·Theoretical immune activation
Contraindications
- ·Pregnancy
- ·Active malignancy
- ·Pediatric
Regulatory
Research peptide — not approved
Functional Groups
Cited Works
- Baar MP et al. Targeted apoptosis of senescent cells via a FOXO4-p53 interfering peptide. Cell. 2017;169:132.source