← Library
HGH Fragment 176-191
Research Use
Also known as Frag 176-191, Lipolytic fragment
Function
Primary
Fat loss (research)
Secondary
Body recomposition
Mechanism
C-terminal fragment of hGH that stimulates beta-3 adrenergic lipolysis in adipocytes without measurable effect on IGF-1 or glucose.
Evidence
Pre-clinical / Observational
Research
Early human trials of AOD-9604 analog failed to beat placebo
Dosing
Range
200–500 mcg/day
Frequency
1–2× daily, fasted
Route
Subcutaneous
Administration & Technique
Subcutaneous (SubQ)
Default route for most research and therapeutic peptides — best absorption for reconstituted powder.
Device31G × 5/16" insulin syringe (U-100). 100 units = 1 mL.
TechniquePinch skin at abdomen (2" from navel), outer thigh, or love handle. Insert at 45–90°. Rotate sites daily to prevent lipohypertrophy. Alcohol-swab site, air-dry, inject slow, hold 5 sec.
Injection & Application Sites
Front
Back
Subcutaneous (SubQ)
- Abdomen — 2 in (5 cm) away from the navel, either side. Fastest, most consistent SubQ absorption.
- Flank / love handle — Lateral fat pad above the hip. Good rotation site when the abdomen is tender.
- Outer thigh — Upper outer quadrant, a hand-width below the hip. SubQ pinch at 45°.
Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.
Cycling
Commonly 8–12 weeks fasted-morning dosing, then a 4-week break.
Timing & Interactions
When to take
No strict time-of-day requirement. Dose consistently at the same time daily and rotate injection sites. Follow the per-peptide dosing section above.
Do not combine with
- ·Avoid stacking with peptides that share the same receptor or mechanism without clinical guidance.
- ·Avoid combining with alcohol or immunosuppressants unless cleared by a clinician.
Complements
- ·Most peptides pair safely with baseline nutrition, sleep, and resistance training.
Storage & Reconstitution
Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Reconstitution Calculator
Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)
1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.
Your Notes
Your Notes
Sign in to save personal notes on HGH Fragment 176-191 and sync them to Vial Lab.
Benefits
- ·Targeted lipolysis without GH-like glucose effects
- ·No reported IGF-1 elevation
Risks
- ·Injection-site reactions
- ·Unproven efficacy in humans
- ·Unregulated purity
Contraindications
- ·Pregnancy or breastfeeding
- ·Unknown safety in malignancy
Regulatory
Research chemical — not approved for human use
Veterinary Use (Pets)
No established veterinary protocol for HGH Fragment 176-191. Consult a licensed veterinarian before considering off-label use in any species.
Full veterinary reference →Functional Groups
Cited Works
- Heffernan M et al. The effects of human GH and its lipolytic fragment (AOD9604). J Clin Endocrinol Metab. 2001;86:5663.source