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Kisspeptin-10
Research Use
Also known as KP-10, Metastin 45-54
Function
Primary
HPG-axis stimulation · Hypothalamic amenorrhea (research)
Secondary
Sexual arousal (investigational)
Mechanism
KISS1R agonist on hypothalamic GnRH neurons — drives pulsatile GnRH release, restoring LH/FSH and downstream sex hormones; modulates limbic arousal circuits.
Evidence
Clinical RCT (Limited)
Research
Phase 1/2 trials at Imperial College & NIH
Dosing
Range
0.3–3 nmol/kg (IV, research)
Frequency
Single or pulsatile dosing in studies
Route
Intravenous · Subcutaneous (research)
Cycling
Not established; protocol-specific.
Benefits
- ·Restores LH/FSH pulsatility
- ·Increases sexual brain activation on fMRI
- ·Possible fertility applications
Risks
- ·Limited safety data
- ·Headache, flushing
- ·Unknown long-term endocrine effects
Contraindications
- ·Hormone-sensitive cancers
- ·Pregnancy unless under fertility care
Regulatory
Investigational
Functional Groups
Cited Works
- Skorupskaite K et al. Kisspeptin and reproductive function. Hum Reprod Update. 2014;20:485.source