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Kisspeptin-10
Research Use
Also known as KP-10, Metastin 45-54
Function
Primary
HPG-axis stimulation · Hypothalamic amenorrhea (research)
Secondary
Sexual arousal (investigational)
Mechanism
KISS1R agonist on hypothalamic GnRH neurons — drives pulsatile GnRH release, restoring LH/FSH and downstream sex hormones; modulates limbic arousal circuits.
Evidence
Clinical RCT (Limited)
Research
Phase 1/2 trials at Imperial College & NIH
Dosing
Range
0.3–3 nmol/kg (IV, research)
Frequency
Single or pulsatile dosing in studies
Route
Intravenous · Subcutaneous (research)
Administration & Technique
Intravenous (IV)
Clinician-administered only. Reserved for hospital protocols, senolytics research, or emergency use.
DeviceIV catheter / infusion pump.
TechniqueSterile IV push or slow infusion per protocol. Not for home use.
Subcutaneous (SubQ)
Default route for most research and therapeutic peptides — best absorption for reconstituted powder.
Device31G × 5/16" insulin syringe (U-100). 100 units = 1 mL.
TechniquePinch skin at abdomen (2" from navel), outer thigh, or love handle. Insert at 45–90°. Rotate sites daily to prevent lipohypertrophy. Alcohol-swab site, air-dry, inject slow, hold 5 sec.
Injection & Application Sites
Front
Back
Intravenous (IV)
- IV — clinician only — Antecubital vein or central line. Not for home administration.
Subcutaneous (SubQ)
- Abdomen — 2 in (5 cm) away from the navel, either side. Fastest, most consistent SubQ absorption.
- Flank / love handle — Lateral fat pad above the hip. Good rotation site when the abdomen is tender.
- Outer thigh — Upper outer quadrant, a hand-width below the hip. SubQ pinch at 45°.
Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.
Cycling
Not established; protocol-specific.
Timing & Interactions
When to take
SubQ, morning. Dosing schedules vary by protocol (research).
Do not combine with
- ·Hormone-sensitive malignancy
Complements
- ·PT-141 / Bremelanotide research stacks
Storage & Reconstitution
Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Reconstitution Calculator
Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)
1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.
Your Notes
Your Notes
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Benefits
- ·Restores LH/FSH pulsatility
- ·Increases sexual brain activation on fMRI
- ·Possible fertility applications
Risks
- ·Limited safety data
- ·Headache, flushing
- ·Unknown long-term endocrine effects
Contraindications
- ·Hormone-sensitive cancers
- ·Pregnancy unless under fertility care
Regulatory
Investigational
Veterinary Use (Pets)
No established veterinary protocol for Kisspeptin-10. Consult a licensed veterinarian before considering off-label use in any species.
Full veterinary reference →Functional Groups
Cited Works
- Skorupskaite K et al. Kisspeptin and reproductive function. Hum Reprod Update. 2014;20:485.source