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Matrixyl (Pal-KTTKS)
Research Use
Also known as Palmitoyl Pentapeptide-4, Pal-KTTKS
Function
Primary
Wrinkles · Dermal collagen support
Mechanism
Lipidated pentapeptide derived from procollagen I C-terminus — signals fibroblasts to upregulate collagen I, III, and fibronectin synthesis.
Evidence
Clinical RCT (Limited)
Research
Multiple split-face cosmetic RCTs
Dosing
Range
3–5% in topical formulation
Frequency
1–2× daily
Route
Topical
Administration & Technique
Topical
Cosmetic anti-aging.
DeviceSerum (3–5% Matrixyl 3000 or Synthe'6).
TechniqueApply to clean skin AM and PM under moisturizer.
Injection & Application Sites
Front
Back
Topical
- Face / neck (topical) — Clean dry skin, AM and PM, before moisturizer.
Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.
Cycling
Continuous topical use.
Timing & Interactions
When to take
Topical, 1–2× daily (AM and/or PM). Layer under moisturizer. Avoid same-application vitamin C or strong acids.
Do not combine with
- ·Concurrent same-time strong acids/retinoids — separate by 12 hrs
Complements
- ·Argireline (AM), GHK-Cu (opposite time of day)
Storage & Reconstitution
Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Reconstitution Calculator
Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)
1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.
Your Notes
Your Notes
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Benefits
- ·Reduced fine lines
- ·Improved skin density
- ·Well tolerated
Risks
- ·Mild irritation (rare)
- ·Slow onset (8–12 weeks)
Contraindications
- ·Active dermatitis on application site
Regulatory
Cosmetic ingredient (global)
Veterinary Use (Pets)
No established veterinary protocol for Matrixyl (Pal-KTTKS). Consult a licensed veterinarian before considering off-label use in any species.
Full veterinary reference →Functional Groups
Cited Works
- Robinson LR et al. Topical palmitoyl pentapeptide (Matrixyl) clinical study. Int J Cosmet Sci. 2005;27:155.source