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Matrixyl (Pal-KTTKS)
Research Use
Also known as Palmitoyl Pentapeptide-4, Pal-KTTKS
Function
Primary
Wrinkles · Dermal collagen support
Mechanism
Lipidated pentapeptide derived from procollagen I C-terminus — signals fibroblasts to upregulate collagen I, III, and fibronectin synthesis.
Evidence
Clinical RCT (Limited)
Research
Multiple split-face cosmetic RCTs
Dosing
Range
3–5% in topical formulation
Frequency
1–2× daily
Route
Topical
Cycling
Continuous topical use.
Benefits
- ·Reduced fine lines
- ·Improved skin density
- ·Well tolerated
Risks
- ·Mild irritation (rare)
- ·Slow onset (8–12 weeks)
Contraindications
- ·Active dermatitis on application site
Regulatory
Cosmetic ingredient (global)
Functional Groups
Cited Works
- Robinson LR et al. Topical palmitoyl pentapeptide (Matrixyl) clinical study. Int J Cosmet Sci. 2005;27:155.source