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Selank
Research Use
Also known as TP-7
Function
Primary
Anxiety · Cognitive enhancement
Secondary
Immunomodulation
Mechanism
Synthetic tuftsin analog — modulates GABA-A activity; increases BDNF expression; reduces enkephalin degradation; anti-inflammatory via IL-6.
Evidence
Pre-clinical / Observational
Research
Russian Phase II/III; limited Western RCTs
Dosing
Range
250–500 mcg/day
Frequency
Once or twice daily
Route
Intranasal · Subcutaneous
Cycling
2–4 week courses, then 2-week break.
Benefits
- ·Anxiolytic without sedation
- ·Improved focus and mood
- ·No dependence reported in Russian data
Risks
- ·Mild sedation
- ·Headache
- ·Limited Western safety review
Contraindications
- ·Pregnancy
- ·Hypersensitivity
Regulatory
Approved in Russia; not FDA-approved
Functional Groups
Cited Works
- Kozlovskaya MM et al. Selank: anxiolytic and nootropic activity. Eksp Klin Farmakol. 2003;66:31.