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Semax
Research Use
Also known as ACTH(4-10) analog
Function
Primary
Cognitive enhancement · Stroke recovery
Secondary
Neuroprotection · ADHD (off-label)
Mechanism
ACTH analog — increases BDNF, NGF, and VEGF expression; enhances dopaminergic/serotonergic tone; neuroprotective via anti-apoptotic mechanisms.
Evidence
Pre-clinical / Observational
Research
Russian approved drug; limited Western peer review
Dosing
Range
300–900 mcg/day
Frequency
Once or twice daily
Route
Intranasal
Cycling
2–4 weeks on / 2 weeks off.
Benefits
- ·Improved memory and focus
- ·Stroke recovery support
- ·Mood modulation
Risks
- ·Mild hypertension
- ·Limited Western long-term data
Contraindications
- ·Uncontrolled hypertension
- ·Pregnancy
Regulatory
Approved in Russia; not FDA-approved
Functional Groups
Cited Works
- Ashmarin IP et al. Semax in the treatment of stroke. Zh Nevrol Psikhiatr. 2005;105:24.