← Library
Thymopentin (TP-5)
Research Use
Also known as TP5, Timunox
Function
Primary
Immune modulation (research)
Mechanism
Active pentapeptide fragment (32-36) of thymopoietin; promotes T-cell maturation and cytokine balance.
Evidence
Clinical RCT (Limited)
Research
Trials in HIV, hepatitis B, and atopic dermatitis
Dosing
Range
1–50 mg per dose depending on protocol
Frequency
3× weekly
Route
Subcutaneous · Intravenous
Administration & Technique
Subcutaneous (SubQ)
Default route for most research and therapeutic peptides — best absorption for reconstituted powder.
Device31G × 5/16" insulin syringe (U-100). 100 units = 1 mL.
TechniquePinch skin at abdomen (2" from navel), outer thigh, or love handle. Insert at 45–90°. Rotate sites daily to prevent lipohypertrophy. Alcohol-swab site, air-dry, inject slow, hold 5 sec.
Intravenous (IV)
Clinician-administered only. Reserved for hospital protocols, senolytics research, or emergency use.
DeviceIV catheter / infusion pump.
TechniqueSterile IV push or slow infusion per protocol. Not for home use.
Injection & Application Sites
Front
Back
Subcutaneous (SubQ)
- Abdomen — 2 in (5 cm) away from the navel, either side. Fastest, most consistent SubQ absorption.
- Flank / love handle — Lateral fat pad above the hip. Good rotation site when the abdomen is tender.
- Outer thigh — Upper outer quadrant, a hand-width below the hip. SubQ pinch at 45°.
Intravenous (IV)
- IV — clinician only — Antecubital vein or central line. Not for home administration.
Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.
Cycling
6–12 week courses with reassessment.
Timing & Interactions
When to take
No strict time-of-day requirement. Dose consistently at the same time daily and rotate injection sites. Follow the per-peptide dosing section above.
Do not combine with
- ·Avoid stacking with peptides that share the same receptor or mechanism without clinical guidance.
- ·Avoid combining with alcohol or immunosuppressants unless cleared by a clinician.
Complements
- ·Most peptides pair safely with baseline nutrition, sleep, and resistance training.
Storage & Reconstitution
Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Reconstitution Calculator
Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)
1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.
Your Notes
Your Notes
Sign in to save personal notes on Thymopentin (TP-5) and sync them to Vial Lab.
Benefits
- ·Improved T-cell counts in immunodeficiency
- ·Adjunct benefit in chronic viral hepatitis studies
Risks
- ·Injection-site pain
- ·Rare hypersensitivity
- ·Autoimmune activation
Contraindications
- ·Autoimmune disease
- ·Organ transplant immunosuppression
- ·Pregnancy
Regulatory
Approved in parts of Europe/Asia; research-only in the US
Veterinary Use (Pets)
No established veterinary protocol for Thymopentin (TP-5). Consult a licensed veterinarian before considering off-label use in any species.
Full veterinary reference →Functional Groups
Cited Works
- Garaci E et al. Thymosin α1: from basic research to clinical use. Expert Opin Biol Ther. 2007;7:1535.source