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VIP (Vasoactive Intestinal Peptide)
Research Use
Also known as Aviptadil
Function
Primary
Chronic inflammatory response research · Pulmonary inflammation
Mechanism
28-amino-acid neuropeptide acting at VPAC1/VPAC2 receptors to produce vasodilation, bronchodilation, and broad anti-inflammatory signaling.
Evidence
Clinical RCT (Limited)
Research
Trials in ARDS and pulmonary hypertension; CIRS protocol use
Dosing
Range
50 mcg 4×/day intranasal (protocol use)
Frequency
Up to 4× daily
Route
Intranasal · Intravenous
Administration & Technique
Intranasal
Preferred for CNS-targeted peptides (nose-to-brain delivery) and rescue formulations.
DeviceMetered nasal spray (0.05–0.1 mL / puff) or dropper.
TechniqueBlow nose first. Tilt head slightly forward. Insert tip, occlude opposite nostril, spray on inhalation. Alternate nostrils. Do not sniff hard — pool in mucosa.
Intravenous (IV)
Clinician-administered only. Reserved for hospital protocols, senolytics research, or emergency use.
DeviceIV catheter / infusion pump.
TechniqueSterile IV push or slow infusion per protocol. Not for home use.
Injection & Application Sites
Front
Back
Intranasal
- Intranasal — Alternate nostrils, spray on inhalation, do not sniff hard.
Intravenous (IV)
- IV — clinician only — Antecubital vein or central line. Not for home administration.
Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.
Cycling
Long taper protocols under clinician supervision.
Timing & Interactions
When to take
No strict time-of-day requirement. Dose consistently at the same time daily and rotate injection sites. Follow the per-peptide dosing section above.
Do not combine with
- ·Avoid stacking with peptides that share the same receptor or mechanism without clinical guidance.
- ·Avoid combining with alcohol or immunosuppressants unless cleared by a clinician.
Complements
- ·Most peptides pair safely with baseline nutrition, sleep, and resistance training.
Storage & Reconstitution
Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Reconstitution Calculator
Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)
1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.
Your Notes
Your Notes
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Benefits
- ·Anti-inflammatory cytokine shift
- ·Reported improvement in CIRS symptom scores
- ·Pulmonary vasodilation
Risks
- ·Hypotension and flushing
- ·Diarrhea
- ·Requires mold/biotoxin remediation first in CIRS protocols
Contraindications
- ·Hypotension
- ·Active mold exposure (protocol requirement)
- ·Pregnancy
Regulatory
Compounded/investigational — no FDA approval for chronic use
Veterinary Use (Pets)
No established veterinary protocol for VIP (Vasoactive Intestinal Peptide). Consult a licensed veterinarian before considering off-label use in any species.
Full veterinary reference →Functional Groups
Cited Works
- Vandamme D et al. A comprehensive summary of LL-37. Cell Immunol. 2012;280:22.source