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AOD-9604
Research Use
Also known as hGH fragment 176-191
Function
Primary
Fat metabolism · Weight management
Secondary
Cartilage repair (off-label)
Mechanism
C-terminal fragment of hGH — activates fat-specific β3-adrenergic receptor; promotes lipolysis without GH's anabolic/diabetogenic effects; possible cartilage regeneration via VEGF.
Evidence
Pre-clinical / Observational
Research
Phase II/III completed (failed primary obesity endpoint)
Dosing
Range
300–600 mcg/day
Frequency
Once daily (fasted)
Route
Subcutaneous
Cycling
8 weeks on / 4 weeks off.
Benefits
- ·Selective lipolysis without GH side effects
- ·No insulin resistance signal
- ·No IGF-1 elevation
Risks
- ·Failed Phase III obesity endpoint
- ·Limited long-term human data
Contraindications
- ·Pregnancy
- ·Hypersensitivity
Regulatory
Not FDA-approved; TGA-approved (Australia, discontinued); research use
Functional Groups
Cited Works
- Heffernan M et al. The effects of human GH and its lipolytic fragment (AOD9604). J Clin Endocrinol Metab. 2001;86:5663.source