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BPC-157
Research Use
Also known as Body Protection Compound 157
Function
Primary
Gut healing · Tendon/ligament repair
Secondary
Neuroprotection · Anti-inflammatory
Mechanism
Upregulates VEGF and growth-factor expression; activates FAK-paxillin pathway for angiogenesis; modulates NO synthesis; interacts with dopaminergic/serotonergic systems.
Evidence
Pre-clinical / Observational
Research
Extensive animal RCTs; human case reports; no Phase II
Dosing
Range
200–500 mcg/day
Frequency
Once or twice daily
Route
Subcutaneous · Oral · Intraperitoneal
Cycling
Typical protocol: 4 weeks on / 2–4 weeks off, repeated 2–3 cycles per year.
Benefits
- ·Reported soft-tissue and tendon repair
- ·GI ulcer healing in animals
- ·Anti-inflammatory in models
- ·Possible neuroprotection
Risks
- ·Limited human safety data
- ·Sourcing/purity concerns from research suppliers
- ·Theoretical angiogenesis in malignancy
Contraindications
- ·Active malignancy (theoretical)
- ·Pregnancy/lactation (unknown safety)
- ·Hypersensitivity
Regulatory
Not FDA-approved; compounded / research use
Functional Groups
Cited Works
- Sikiric P et al. BPC 157, A Body Protection Compound: Review. Curr Pharm Des. 2018;24:1990-2001.source