← Library
DSIP
Research Use
Also known as Delta Sleep-Inducing Peptide
Function
Primary
Sleep quality · Insomnia
Secondary
Stress response normalization
Mechanism
Hypothalamic peptide — reduces ACTH and somatostatin secretion; modulates delta-wave EEG sleep; antioxidant; normalizes circadian disruption.
Evidence
Pre-clinical / Observational
Research
Small human studies (1970s–80s)
Dosing
Range
100–400 mcg/day
Frequency
Before sleep
Route
Subcutaneous · Intranasal
Cycling
2–3 weeks on / 1 week off.
Benefits
- ·Deeper delta-wave sleep
- ·Stress normalization
- ·Antioxidant in models
Risks
- ·Variable absorption
- ·Anecdotal tolerance with frequent use
- ·Limited modern safety data
Contraindications
- ·Pregnancy
- ·Hypersensitivity
Regulatory
Not FDA-approved; research use
Functional Groups
Cited Works
- Schoenenberger GA. DSIP: a still unresolved riddle. J Neural Transm. 1984;21:367.