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Follistatin 344
Research Use
Also known as FST-344
Function
Primary
Muscle growth · Anti-fibrotic
Secondary
Fertility (research)
Mechanism
Activin/myostatin antagonist — binds and neutralizes myostatin and activin A; promotes satellite-cell activation and muscle hypertrophy; reduces fibrosis.
Evidence
Pre-clinical / Observational
Research
Gene therapy trials ongoing; limited protein-form human data
Dosing
Range
100 mcg/dose (experimental)
Frequency
Variable (research protocols only)
Route
Intramuscular · Subcutaneous
Cycling
Research protocols only — not for routine use.
Benefits
- ·Muscle hypertrophy in models
- ·Anti-fibrotic
- ·Potential for sarcopenia (theoretical)
Risks
- ·Oncogenicity concern (myostatin suppression)
- ·Gene-therapy safety unknowns
- ·No approved human dosing
Contraindications
- ·Active malignancy
- ·Pregnancy
- ·Pediatric
Regulatory
Not FDA-approved; research use only
Functional Groups
Cited Works
- Lee SJ. Quadrupling muscle mass in mice by targeting myostatin & follistatin. PLoS ONE. 2007;2:e789.source