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Hexarelin

Peptide Index
Research Use
Also known as Examorelin, EP 23905
Interaction Warning3 flagged
Do not combine Hexarelin with the following:
  • Other GHRPs
  • MK
  • Concurrent long

Function

Primary
GH secretagogue · Cardioprotection (research)
Secondary
Body composition
Mechanism
Potent ghrelin / GHS-R1a agonist — stimulates pituitary GH release; direct cardioprotective effects via GHS-R1b on cardiomyocytes; reduces cardiac fibrosis.
Evidence
Pre-clinical / Observational
Research
Phase I/II cardiac studies; robust GH-axis data

Dosing

Range
100–200 mcg/dose
Frequency
1–2× daily
Route
Subcutaneous

Administration & Technique

Subcutaneous (SubQ)
Default route for most research and therapeutic peptides — best absorption for reconstituted powder.
Device31G × 5/16" insulin syringe (U-100). 100 units = 1 mL.
TechniquePinch skin at abdomen (2" from navel), outer thigh, or love handle. Insert at 45–90°. Rotate sites daily to prevent lipohypertrophy. Alcohol-swab site, air-dry, inject slow, hold 5 sec.

Injection & Application Sites

Front
Back
Subcutaneous (SubQ)
  • Abdomen — 2 in (5 cm) away from the navel, either side. Fastest, most consistent SubQ absorption.
  • Flank / love handle — Lateral fat pad above the hip. Good rotation site when the abdomen is tender.
  • Outer thigh — Upper outer quadrant, a hand-width below the hip. SubQ pinch at 45°.

Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.

Cycling

Pulsed: 4 weeks on / 4 weeks off.

Timing & Interactions

When to take
1–2× daily fasted, short cycles only (4 weeks max). Desensitization occurs rapidly.
Do not combine with
  • ·Other GHRPs — same class
  • ·MK-677
  • ·Concurrent long-term GH therapy
Complements
  • ·Short pairing with CJC-1295 / Mod GRF for pulse amplification
Notes
Highest cortisol/prolactin bump of the GHRPs.

Storage & Reconstitution

Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Full BAC water & reconstitution guide →

Reconstitution Calculator

Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)

1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.

Your Notes

Your Notes

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Benefits

  • ·Strong GH release
  • ·Cardioprotective signaling in models
  • ·Body composition support

Risks

  • ·Rapid desensitization with chronic use
  • ·Elevated cortisol and prolactin
  • ·Hunger stimulation

Contraindications

  • ·Active malignancy
  • ·Pregnancy

Regulatory

Not FDA-approved; research use

Veterinary Use (Pets)

No established veterinary protocol for Hexarelin. Consult a licensed veterinarian before considering off-label use in any species.

Full veterinary reference →

Functional Groups

Men's HealthRecoveryLongevityBodybuilding & Performance

Cited Works

  1. Imbimbo BP et al. Hexarelin: a novel GH-releasing peptide. J Endocrinol Invest. 1994;17:325.
View full reference repository →
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