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Humanin
Research Use
Also known as HN, HNG analog
Function
Primary
Neuroprotection · Metabolic stress (research)
Mechanism
24-aa mitochondrial-derived peptide — binds IGFBP-3, suppresses Bax-mediated apoptosis; cytoprotective against amyloid-β and oxidative stress.
Evidence
Pre-clinical / Observational
Research
Pre-clinical neurodegeneration & cardiometabolic models
Dosing
Range
Research dosing only
Frequency
Variable
Route
Subcutaneous · Intranasal (research)
Cycling
Not established.
Benefits
- ·Neuroprotection in AD models
- ·Cardioprotection
- ·Improved insulin action
Risks
- ·Unknown human safety
- ·Potential mitogenic effects (theoretical)
Contraindications
- ·Pregnancy
- ·Active malignancy
Regulatory
Research peptide — not approved
Functional Groups
Cited Works
- Hashimoto Y et al. A rescue factor for Alzheimer's disease: Humanin. Proc Natl Acad Sci. 2001;98:6336.source