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IGF-1 LR3
Research Use
Also known as Long R3 IGF-1
Function
Primary
Muscle hypertrophy (research) · Tissue repair
Mechanism
Modified IGF-1 with reduced IGFBP affinity and ~3× longer half-life — sustained activation of IGF-1R driving protein synthesis and satellite-cell activity.
Evidence
Pre-clinical / Observational
Research
No human Phase trials; rodent hypertrophy data
Dosing
Range
20–80 mcg/day (anecdotal)
Frequency
Daily, often pre-workout
Route
Subcutaneous · Intramuscular
Administration & Technique
Subcutaneous
Post-workout, systemic.
DeviceInsulin syringe.
TechniqueAbdomen SubQ. Pair with a small protein/carb meal within 30 min.
Local Injection
Site-specific hypertrophy protocols (research).
Device30G insulin syringe.
TechniqueBilateral SubQ over trained muscle groups.
Injection & Application Sites
Front
Back
Subcutaneous
- Abdomen — 2 in (5 cm) away from the navel, either side. Fastest, most consistent SubQ absorption.
Local Injection
- Over the target / injured muscle — SubQ directly above the trained or injured muscle. Never intra-articular without imaging.
Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.
Cycling
Short cycles (4–6 weeks) reported; no validated protocol.
Timing & Interactions
When to take
Once daily post-workout (or on training days only). Some split AM/PM. Take with a small protein/carb meal within 30 min.
Do not combine with
- ·Concurrent MK-677 or heavy GH — hypoglycemia + IGF overload
- ·Active or suspected cancer — mitogenic risk
Complements
- ·Short pairing with GHRP/GHRH stacks during a training block
Notes
Monitor blood glucose, especially first week.
Storage & Reconstitution
Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Reconstitution Calculator
Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)
1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.
Your Notes
Your Notes
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Benefits
- ·Anabolic muscle growth
- ·Enhanced recovery
- ·Improved nutrient partitioning
Risks
- ·Hypoglycemia
- ·Organ growth / cardiomegaly with chronic use
- ·Possible tumor promotion
- ·Jaw / soft tissue overgrowth
Contraindications
- ·Active or prior cancer
- ·Diabetic retinopathy
- ·Pregnancy
Regulatory
Research chemical — banned by WADA
Veterinary Use (Pets)
No established veterinary protocol for IGF-1 LR3. Consult a licensed veterinarian before considering off-label use in any species.
Full veterinary reference →Functional Groups
Cited Works
- Tomas FM et al. Long-R3-IGF-I promotes nitrogen retention in rats. J Endocrinol. 1993;137:413.source