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IGF-1 LR3
Research Use
Also known as Long R3 IGF-1
Function
Primary
Muscle hypertrophy (research) · Tissue repair
Mechanism
Modified IGF-1 with reduced IGFBP affinity and ~3× longer half-life — sustained activation of IGF-1R driving protein synthesis and satellite-cell activity.
Evidence
Pre-clinical / Observational
Research
No human Phase trials; rodent hypertrophy data
Dosing
Range
20–80 mcg/day (anecdotal)
Frequency
Daily, often pre-workout
Route
Subcutaneous · Intramuscular
Cycling
Short cycles (4–6 weeks) reported; no validated protocol.
Benefits
- ·Anabolic muscle growth
- ·Enhanced recovery
- ·Improved nutrient partitioning
Risks
- ·Hypoglycemia
- ·Organ growth / cardiomegaly with chronic use
- ·Possible tumor promotion
- ·Jaw / soft tissue overgrowth
Contraindications
- ·Active or prior cancer
- ·Diabetic retinopathy
- ·Pregnancy
Regulatory
Research chemical — banned by WADA
Functional Groups
Cited Works
- Tomas FM et al. Long-R3-IGF-I promotes nitrogen retention in rats. J Endocrinol. 1993;137:413.source