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MGF (Mechano Growth Factor)

Peptide Index
Research Use
Also known as IGF-1Ec, Non-PEG MGF
Interaction Warning2 flagged
Do not combine MGF (Mechano Growth Factor) with the following:
  • Avoid stacking with peptides that share the same receptor or mechanism without clinical guidance.
  • Avoid combining with alcohol or immunosuppressants unless cleared by a clinician.

Function

Primary
Muscle repair after mechanical load (research)
Mechanism
Splice variant of IGF-1 released by damaged muscle; recruits and proliferates satellite cells before differentiating into new myotubes.
Evidence
Pre-clinical / Observational
Research
Animal and in-vitro data; no controlled human trials

Dosing

Range
100–200 mcg per site
Frequency
Immediately post-training
Route
Subcutaneous · Intramuscular

Administration & Technique

Subcutaneous (SubQ)
Default route for most research and therapeutic peptides — best absorption for reconstituted powder.
Device31G × 5/16" insulin syringe (U-100). 100 units = 1 mL.
TechniquePinch skin at abdomen (2" from navel), outer thigh, or love handle. Insert at 45–90°. Rotate sites daily to prevent lipohypertrophy. Alcohol-swab site, air-dry, inject slow, hold 5 sec.
Intramuscular (IM)
Used for depot formulations, some GH secretagogues (localized delivery), and clinical protocols requiring faster systemic uptake.
Device23–25G × 1–1.5" needle. 1–3 mL syringe.
TechniqueVentrogluteal, vastus lateralis, or deltoid. Insert 90°, aspirate (optional), inject slowly. Rotate sites weekly.

Injection & Application Sites

Front
Back
Subcutaneous (SubQ)
  • Abdomen — 2 in (5 cm) away from the navel, either side. Fastest, most consistent SubQ absorption.
  • Flank / love handle — Lateral fat pad above the hip. Good rotation site when the abdomen is tender.
  • Outer thigh — Upper outer quadrant, a hand-width below the hip. SubQ pinch at 45°.
Intramuscular (IM)
  • Ventrogluteal — Palm on greater trochanter, index to ASIS — inject in the V. Safest IM site.
  • Dorsogluteal (upper outer) — Upper outer quadrant of the buttock. Used for depot IM; alternate sides each cycle.
  • Upper arm / deltoid — Back of the upper arm for SubQ; 2 in below the shoulder bone for IM.
  • Anterior thigh (vastus lateralis) — Middle third of the outer front thigh. Preferred IM site for self-injection.

Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.

Cycling

Typically 4–6 weeks alongside a GH secretagogue.

Timing & Interactions

When to take
No strict time-of-day requirement. Dose consistently at the same time daily and rotate injection sites. Follow the per-peptide dosing section above.
Do not combine with
  • ·Avoid stacking with peptides that share the same receptor or mechanism without clinical guidance.
  • ·Avoid combining with alcohol or immunosuppressants unless cleared by a clinician.
Complements
  • ·Most peptides pair safely with baseline nutrition, sleep, and resistance training.

Storage & Reconstitution

Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Full BAC water & reconstitution guide →

Reconstitution Calculator

Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)

1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.

Your Notes

Your Notes

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Benefits

  • ·Satellite-cell recruitment
  • ·Possible faster repair of trained muscle

Risks

  • ·Very short half-life (minutes) limits effect
  • ·Injection-site irritation
  • ·Unknown long-term safety

Contraindications

  • ·Active malignancy
  • ·Pregnancy

Regulatory

Research chemical — WADA-banned

Veterinary Use (Pets)

No established veterinary protocol for MGF (Mechano Growth Factor). Consult a licensed veterinarian before considering off-label use in any species.

Full veterinary reference →

Functional Groups

Bodybuilding & PerformanceRecovery

Cited Works

  1. Lee SJ. Quadrupling muscle mass in mice by targeting myostatin & follistatin. PLoS ONE. 2007;2:e789.source
View full reference repository →
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