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PEG-MGF
Research Use
Also known as Pegylated Mechano-Growth Factor, IGF-1Ec
Function
Primary
Muscle repair (research)
Mechanism
PEGylated splice variant of IGF-1 (MGF / IGF-1Ec) — activates muscle satellite cells in response to mechanical loading; PEGylation extends half-life.
Evidence
Pre-clinical / Observational
Research
Pre-clinical only
Dosing
Range
100–200 mcg, 2–3×/week (anecdotal)
Frequency
Post-workout / multiple weekly
Route
Subcutaneous · Intramuscular
Administration & Technique
Local Injection
Post-workout, near trained muscle.
Device29–30G × 1/2" insulin syringe.
TechniqueSubQ directly over the target muscle within 30 min of training. 1–3× / week.
Injection & Application Sites
Front
Back
Local Injection
- Over the target / injured muscle — SubQ directly above the trained or injured muscle. Never intra-articular without imaging.
Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.
Cycling
4–8 week cycles in user protocols.
Timing & Interactions
When to take
Post-workout only, injected locally near trained muscle groups. 1–3× per week on training days.
Do not combine with
- ·Concurrent IGF-1 LR3 same site — additive mitogenic load
Complements
- ·IGF-1 LR3 on alternate days
- ·GH secretagogue stacks
Storage & Reconstitution
Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Reconstitution Calculator
Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)
1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.
Your Notes
Your Notes
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Benefits
- ·Satellite cell activation
- ·Localized hypertrophy / repair
- ·Potential tendon repair
Risks
- ·Hypoglycemia
- ·Theoretical tumor promotion
- ·Injection-site reactions
Contraindications
- ·Cancer history
- ·Pregnancy
Regulatory
Research chemical — banned by WADA
Veterinary Use (Pets)
Occasional use in equine sports medicine for post-injury local hypertrophy.
Horses (Equine)
Dose1–2 mg local SubQ over injured muscle 1–2× weekly
RouteLocal SubQ
UseMuscle/tendon rehab.
Prohibited in racing/FEI competition.
Functional Groups
Cited Works
- Goldspink G. Mechano-Growth Factor: a target for hypertrophy & repair. J Musculoskelet Neuronal Interact. 2005;5:344.