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Pinealon
Research Use
Also known as EW-3, Glu-Asp-Arg
Function
Primary
Neuroprotection · Sleep regulation
Secondary
Cognitive aging · Antioxidant
Mechanism
Tripeptide — penetrates blood–brain barrier; modulates gene expression for neuroprotection; antioxidant; circadian rhythm regulation via epigenetic mechanisms.
Evidence
Pre-clinical / Observational
Research
Russian lab and animal data (Khavinson)
Dosing
Range
5–10 mg/day (cycle-based)
Frequency
Daily (cycles)
Route
Subcutaneous · Intranasal
Cycling
10–20 days, repeated 2–3 cycles per year.
Benefits
- ·Neuroprotective in models
- ·Sleep and circadian support
- ·Antioxidant
Risks
- ·Very limited Western human data
- ·Theoretical safety only
Contraindications
- ·Pregnancy
- ·Active malignancy
Regulatory
Not FDA-approved; Russian research peptide
Functional Groups
Cited Works
- Khavinson VK et al. Peptidergic regulation of aging. Adv Gerontol. 2014;27:257.