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Sermorelin
FDA ApprovedSince 1990
Also known as Geref
Function
Primary
Growth Hormone Deficiency (pediatric)
Secondary
Adult GH optimization (compounded, off-label)
Mechanism
GHRH receptor agonist — stimulates pituitary to secrete endogenous GH; physiological pulsatile release preserved.
Evidence
Clinical RCT (Phase III)
Research
Phase III pediatric GH trials
Dosing
Range
0.2–0.3 mg/day
Frequency
Daily at bedtime
Route
Subcutaneous
Administration & Technique
Subcutaneous (SubQ)
Default route for most research and therapeutic peptides — best absorption for reconstituted powder.
Device31G × 5/16" insulin syringe (U-100). 100 units = 1 mL.
TechniquePinch skin at abdomen (2" from navel), outer thigh, or love handle. Insert at 45–90°. Rotate sites daily to prevent lipohypertrophy. Alcohol-swab site, air-dry, inject slow, hold 5 sec.
Injection & Application Sites
Front
Back
Subcutaneous (SubQ)
- Abdomen — 2 in (5 cm) away from the navel, either side. Fastest, most consistent SubQ absorption.
- Flank / love handle — Lateral fat pad above the hip. Good rotation site when the abdomen is tender.
- Outer thigh — Upper outer quadrant, a hand-width below the hip. SubQ pinch at 45°.
Diagram is a general illustration, not a medical instruction. Rotate sites every injection, keep 1 in (2.5 cm) between recent sites, and avoid scars, moles, bruises and the navel area.
Cycling
Commonly 5-day-on / 2-day-off; or 3 months on, 1 month off (off-label).
Timing & Interactions
When to take
Once daily at bedtime on an empty stomach — leverages nocturnal GH surge.
Do not combine with
- ·Other GHRH analogs (CJC-1295, Tesamorelin)
- ·Meals within 30 min
Complements
- ·Ipamorelin for GHRH + GHRP synergy
Storage & Reconstitution
Powder (Pre-Reconstitution)
Lyophilized powder: refrigerate 2–8°C for up to 24 months, or freeze at –20°C for extended storage. Keep sealed, desiccated, and protected from light.
After Reconstitution
After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 28 days. Discard if cloudy, discolored, or precipitated.
Notes
Do not freeze after reconstitution — freeze/thaw cycles degrade most peptides.
Reconstitution Calculator
Concentration
2.50 mg/mL
Volume per dose
0.100 mL
Insulin syringe
10.0 units (U-100)
1 mL = 100 units on a standard U-100 insulin syringe. Draw to the nearest 0.5 unit and confirm dosing with a clinician before injection.
Your Notes
Your Notes
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Benefits
- ·Preserves physiologic GH pulsatility
- ·Improves sleep quality
- ·Lean body mass support (off-label)
Risks
- ·Flushing
- ·Injection site reactions
- ·Headache
- ·Theoretical IGF-1 elevation
Contraindications
- ·Active malignancy
- ·Hypersensitivity to GHRH
- ·Pregnancy
Regulatory
FDA-Approved Rx (discontinued); Compounded Rx available
Veterinary Use (Pets)
No established veterinary protocol for Sermorelin. Consult a licensed veterinarian before considering off-label use in any species.
Full veterinary reference →Functional Groups
Cited Works
- Serono. Geref (sermorelin) Prescribing Information (discontinued 2008).